You don't need to add an item first. Just make sure that you set up everything with the "data mapping" so your spreadsheet and Quickbooks are all speaking the same language.
You should be able to use all of the fields necessary, including item #s, prices, costs, vendors, etc. Data mapping just makes certain that your "Supplier" column equals the "Vendor" that Quickbooks calls it.
Of course there may be some issue if your vendors are not in Quickbooks. As I haven't ever done this myself, I cannot provide you with much more information. But I do know what you're doing is feasible.
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